Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Celiac Disease Comprehensive Panel testing

• Confirms whether gluten triggers your immune system to attack your intestine.
• Spots celiac disease early, before severe nutrient deficiencies or complications develop.
• Clarifies unexplained anemia, fatigue, bloating, or weight loss tied to gluten.
• Guides whether a strict gluten-free diet is medically necessary for you.
• Flags risk for osteoporosis, infertility, and neurological problems if untreated.
• Tracks antibody levels after diagnosis to confirm your diet is working.
• Best interpreted while eating gluten regularly; results may be falsely negative otherwise.

What is Celiac Disease Comprehensive Panel?

The Celiac Disease Comprehensive Panel is a group of blood tests that detect specific antibodies your immune system produces when it mistakenly attacks gluten proteins. These antibodies include tissue transglutaminase (tTG), endomysial antibodies (EMA), and deamidated gliadin peptides (DGP), along with total immunoglobulin A (IgA) to ensure your immune system can make antibodies normally.

Your immune system's fingerprint for gluten reactions

When someone with celiac disease eats gluten, their immune system treats it as a threat and creates these specialized antibodies. The antibodies don't just target gluten itself. They also attack tissue transglutaminase, an enzyme in your intestinal lining, causing inflammation and damage.

Why a panel beats a single test

Testing multiple antibodies together increases accuracy because different antibodies appear at different stages or in different people. The IgA measurement is critical because some people are IgA-deficient, which would cause false-negative results on the other tests. This comprehensive approach helps confirm whether your immune system is reacting to gluten in the characteristic pattern of celiac disease.

Why is Celiac Disease Comprehensive Panel important?

The Celiac Disease Comprehensive Panel measures antibodies your immune system produces when gluten triggers an autoimmune attack on the small intestine. This panel reveals whether your body is mistakenly treating gluten as a threat, damaging the villi that absorb nutrients and setting off a cascade that affects digestion, bone health, fertility, neurologic function, and long-term cancer risk.

When the panel comes back negative

Absent or very low antibody levels suggest your immune system tolerates gluten normally. Your intestinal lining remains intact, nutrient absorption proceeds smoothly, and you avoid the fatigue, anemia, and bone loss that untreated celiac disease can cause. Negative results also help rule out celiac disease in people with unexplained symptoms, guiding clinicians toward other diagnoses.

When antibodies are elevated

High antibody titers signal active autoimmune inflammation in the small intestine. Over time, this erodes the absorptive surface, leading to iron and calcium deficiency, osteoporosis, infertility, and neurologic symptoms like peripheral neuropathy or ataxia. Children may experience stunted growth and delayed puberty. Women with untreated celiac face higher miscarriage rates and menstrual irregularities.

The bigger metabolic picture

Because the small intestine governs nutrient entry into the bloodstream, untreated celiac disease reverberates across every organ system. It raises the risk of lymphoma, other autoimmune conditions like type 1 diabetes and thyroid disease, and chronic malnutrition despite adequate food intake. Early detection protects long-term health and quality of life.

What do my Celiac Disease Comprehensive Panel results mean?

Low or negative values usually reflect absence of immune reactivity

A negative panel means your immune system is not producing antibodies against tissue transglutaminase, endomysial antigens, or deamidated gliadin peptides. This typically indicates you are not mounting an autoimmune response to gluten and suggests celiac disease is unlikely. In someone already following a strict gluten-free diet, antibody levels naturally fall, so a negative result may reflect dietary adherence rather than absence of disease.

Normal or negative results suggest no active autoimmune response to gluten

Being in range means your immune system is not reacting to gluten in a way that damages the small intestinal lining. This supports normal nutrient absorption and intestinal barrier function. It does not rule out non-celiac gluten sensitivity, which does not involve these specific antibodies.

High or positive values usually reflect an autoimmune reaction to gluten

Elevated antibodies indicate your immune system is attacking tissue transglutaminase and related proteins in response to gluten exposure. This autoimmune process damages the villi of the small intestine, impairing absorption of iron, calcium, folate, and fat-soluble vitamins. Symptoms range from diarrhea and bloating to anemia, osteoporosis, and neurologic changes.

Interpretation depends on recent gluten intake and testing context

Results are only accurate if you have been consuming gluten regularly for several weeks before testing. IgA deficiency can cause false negatives, so total IgA is often measured alongside. Biopsy remains the diagnostic gold standard.