Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of ADMA testing

• Reveals how well your blood vessels relax and deliver oxygen throughout your body.
• Flags early cardiovascular risk before symptoms like chest pain or fatigue appear.
• Explains stubborn high blood pressure that doesn't respond well to standard treatment.
• Guides personalized strategies to protect heart and kidney health over time.
• Tracks vascular inflammation and oxidative stress that accelerate aging and disease.
• Clarifies metabolic imbalances linked to diabetes, insulin resistance, and chronic kidney disease.
• Best interpreted alongside lipid panels, kidney function tests, and your clinical symptoms.

What is ADMA?

ADMA (asymmetric dimethylarginine) is a small molecule produced naturally inside your cells when proteins break down. It forms when an amino acid called arginine gets chemically modified with methyl groups, then released during normal protein turnover. Every cell in your body makes ADMA, and it circulates in your bloodstream.

ADMA blocks your body's master relaxation signal

ADMA acts as a brake on nitric oxide, a crucial signaling molecule that relaxes blood vessels and keeps them flexible. It does this by blocking the enzyme (nitric oxide synthase) that produces nitric oxide from arginine. When ADMA levels rise, blood vessels become stiffer and less able to dilate properly.

A window into vascular health

Because ADMA interferes with nitric oxide production, it serves as a marker of endothelial function - the health of the delicate inner lining of your blood vessels. Elevated ADMA reflects oxidative stress, inflammation, and impaired vascular relaxation, making it a biomarker of cardiovascular risk and metabolic dysfunction.

Why is ADMA important?

ADMA (asymmetric dimethylarginine) is a naturally occurring molecule that blocks nitric oxide production in your blood vessels. Nitric oxide keeps arteries relaxed and blood flowing smoothly, so when ADMA rises, your vascular system stiffens, blood pressure climbs, and oxygen delivery to organs falters. This biomarker reflects the health of your endothelium - the inner lining of every artery - and predicts cardiovascular risk more precisely than cholesterol alone.

Normal ADMA levels typically range from 0.4 to 0.7 micromoles per liter, with optimal values sitting toward the lower end. Higher values within or above this range signal endothelial dysfunction, insulin resistance, and chronic inflammation.

When ADMA stays low, your arteries stay flexible

Values at the lower end of normal reflect robust nitric oxide activity and healthy endothelial function. Blood flows freely, blood pressure remains stable, and tissues receive oxygen efficiently. This state supports metabolic health, cognitive clarity, and cardiovascular resilience across the lifespan.

Elevated ADMA tightens the vascular system

When ADMA rises, nitric oxide drops and arteries constrict. This drives hypertension, accelerates atherosclerosis, and impairs kidney filtration. Symptoms may include fatigue, poor exercise tolerance, and cognitive fog. Women with preeclampsia and individuals with diabetes or chronic kidney disease often show marked elevations.

ADMA connects metabolism, inflammation, and long-term vascular aging

Because ADMA integrates oxidative stress, kidney function, and metabolic health, it serves as a window into systemic aging. Persistently high levels forecast heart attack, stroke, and progressive organ damage, making it a powerful marker of biological - not just chronological - age.

What do my ADMA results mean?

Low ADMA levels

Low values usually reflect efficient clearance of this endogenous nitric oxide inhibitor, which generally supports healthy vascular function. ADMA is produced during normal protein turnover and is primarily broken down by the enzyme DDAH. When ADMA levels are low, nitric oxide signaling tends to be preserved, allowing blood vessels to relax and dilate appropriately. This is typically seen in metabolically healthy individuals with good kidney function and low oxidative stress. Low ADMA is not considered a clinical concern and may indicate favorable endothelial health.

Optimal ADMA levels

Being in range suggests balanced nitric oxide regulation and healthy endothelial function. ADMA levels that sit in the lower half of the reference range are generally associated with better vascular responsiveness and lower cardiovascular risk. Optimal values reflect efficient enzymatic breakdown of ADMA and minimal accumulation from inflammation or metabolic stress.

High ADMA levels

High values usually reflect impaired breakdown or increased production of this nitric oxide inhibitor, leading to reduced vascular relaxation and endothelial dysfunction. Elevated ADMA is commonly seen with kidney impairment, insulin resistance, chronic inflammation, oxidative stress, and cardiovascular disease. It contributes to arterial stiffness and reduced blood flow.

Factors that influence ADMA

ADMA rises with age, kidney dysfunction, diabetes, and inflammatory conditions. It may also be elevated during acute illness or with certain medications that affect renal clearance or oxidative balance.