OneTwenty vs SiPhox Health

What is OneTwenty, and what is SiPhox Health?

OneTwenty presents itself as a physical that does not wait for your next physical. Every quarter brings a blood panel, every day brings device data, and the protocol updates as either one changes. It is still taking founding members, and its founding-member pricing ends at public launch.

SiPhox Health leads with a different promise: at-home testing that is fast and painless, with no needles, lab visits, or waiting rooms. You pick a panel, collect a sample yourself, and read the report online.

Both wrap blood work in an action plan. They diverge on how the blood is collected and who decides how often it repeats.

What does OneTwenty include?

One OneTwenty annual fee pays for the baseline, three targeted retests, coaching, an AI assistant, and an action plan. Supplement packs and medications are billed separately.

Its five-step flow reads:

1. Sign up — Start as a founding member.
2. Schedule labs — Choose a walk-in lab or an at-home phlebotomist, with an independent licensed provider ordering the panel.
3. Connect devices and past labs — Bring in the ring, scale, or monitor you own, plus earlier lab history.
4. Results plus action plan — Labs and body data combine into a protocol, which a coach reviews with you.
5. Retest quarterly — Each new panel focuses on the markers still worth watching.

Members can also import results from other labs without a cap. OneTwenty describes itself as a membership, not a medical practice, and clinical care comes from independent providers.

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What does SiPhox Health include?

SiPhox's membership lets you choose among four core panels. It adds a health report with an action plan, supplement suggestions, the Sai assistant, and an in-app body composition scan. Third-party results can be uploaded without limit.

SiPhox explains its model in four steps:

1. Join SiPhox Health — Subscribe and set your own pace.
2. Select your health focus — Match a panel to your priority, from longevity to thyroid, hormones, or heart and metabolic health.
3. Test at home, painlessly — Take a small upper-arm sample with the EasyDraw kit.
4. Get insights & optimize — Open your analysis, then ask Sai about what changed.

A paid $50 coaching credit buys human guidance, as a video call or a written plan.

What biomarkers do OneTwenty and SiPhox Health measure in 2026?

OneTwenty lists 101 markers at baseline and adds three targeted panels. SiPhox publishes 31 markers on Longevity Essentials and 62 on Ultimate 360, per kit.

Both counts mix direct measurements with calculated values. OneTwenty's list includes urinalysis (21 urine results), and no SiPhox panel does.

OneTwenty's baseline is the broader first test. SiPhox's range depends on the panel: Ultimate 360 is a paid upgrade over the four core panels.

OneTwenty's extras are:

• Custom Packs — A supplement pack formulated from your latest panel, billed monthly.
• Medications — Medications and hormone therapy through independent providers, billed monthly. A prescription also puts the markers it touches on your next quarterly panel.
• Devices — Additional monitors at member pricing.

SiPhox's extras are:

• Blood add-ons — A complete blood count, IGF-1, or both for $100.
• Swap-in panels — Ultimate 360, or a medication-monitoring panel at +$75.
• Shop tests — Gut, food and environmental allergy, stress and sleep cortisol, and a Prenuvo scan bundle.

What are the official 2026 membership prices for OneTwenty and SiPhox Health?

OneTwenty costs $499 a year at founding-member pricing, and $749 in New York and New Jersey. SiPhox Health charges $99 for a first kit, then $124 plus $25 shipping per kit.

OneTwenty's fee bills annually and renews at the then-current rate, covers a walk-in draw, and charges $99 for an at-home phlebotomist. Custom Packs start at $67 a month and medications at $49 a month.

SiPhox's yearly total depends on the cadence you pick: 2 kits, 4 kits, or 12. Ultimate 360 adds $125 to a kit, and a complete blood count adds $45.

Both companies say HSA and FSA funds apply. OneTwenty's HSA/FSA reimbursement claim carries an asterisk, since eligibility turns on the member's own plan.

Venous draw or EasyDraw: how each one takes your sample

OneTwenty's draws are venous. Members visit a walk-in lab at no extra cost or book a phlebotomist at home for $99. An independent licensed provider orders the panel.

SiPhox puts the collection in your hands. Its EasyDraw kit draws from the upper arm in about five minutes, with live guidance, and the sample goes overnight to a CLIA-certified lab.

Appointments are the deciding trade. OneTwenty offers a clinical-style draw and a person at your door. SiPhox removes the appointment and asks you to do the draw.

Preset quarterly panels or a cadence you choose

OneTwenty runs a set annual cycle: a full baseline, then targeted retests shaped by your baseline results. You do not set the cadence.

SiPhox lets you set monthly, quarterly, or every 6 months, and you can change panels between kits. You can also pause or cancel from your account.

OneTwenty gives structure that tracks what needs watching. SiPhox gives flexibility that you steer yourself.

Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

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Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

Book your testLoading...

Who guides the plan: a coach, an AI, or a coaching credit?

OneTwenty includes a dedicated health coach, and its AI assistant watches incoming data and flags what deserves a closer look. Labs and devices also feed a One Health Score from 0 to 100. Wearables connect too: Oura and Withings link directly, and other devices come through Apple Health or Google Fit.

SiPhox describes an expert-reviewed report and a Sai assistant that is not a medical doctor. It lists more than 300 supported devices, and human coaching is bought separately.

Medication access also differs. OneTwenty routes it through independent licensed providers for any member. Its stated order tries lifestyle and supplements first, then medication when the data and a provider support it. SiPhox's Heart and Metabolic Program members reach an independent provider group for medication management.

Where are OneTwenty and SiPhox Health tests available?

OneTwenty is available in 49 states, with Rhode Island the exception. New York and New Jersey members pay $749 at founding-member pricing because state rules keep OneTwenty from using its usual lab network.

SiPhox Health does not yet serve Hawaii or New York. Service extends to Canada.

Who is OneTwenty best for, and who is SiPhox Health best for?

OneTwenty is best for:

• People who want a wide baseline and a coach in a single annual membership
• People who want venous draws, including a phlebotomist at home
• People in New York, where SiPhox does not operate

SiPhox Health is best for:

• People who want a needle-free sample from home
• People who want to pick the panel and testing rhythm themselves
• People who want a low entry price, with $99 for the first kit

The bottom line

OneTwenty and SiPhox Health use blood data in different ways. OneTwenty gives a structured year, with a wide baseline, targeted retests, a coach, and daily device sync. SiPhox gives a flexible kit, with painless collection and a panel you choose and repeat.

Each covers only part of what comes next. OneTwenty sells supplement packs and medications but no add-on tests or scans, and SiPhox's shop sells tests and a scan bundle but no supplements.

Superpower puts all three in one membership's marketplace. At $199 a year in most states, it costs less than OneTwenty's $499 founding-member price, and its one draw measures 100+ biomarkers, with add-on tests and scans beside it. Supplements are up to 20% off in the marketplace, and prescriptions are available when clinically appropriate, priced separately. AI and care team support and your Superpower Protocol keep working as new results and wearable data arrive. Superpower says 93% of members found their action plan more useful, even life-changing, than a yearly checkup.

Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.