Key takeaway:
What is Empirical Health, and what is SiPhox Health?
Empirical Health is a heart-focused service: a one-time blood panel, risk scores in its app, and a doctor behind the results.
SiPhox Health leads with "At-Home Health Testing. Fast. Painless." You collect a sample at home, send it off, and choose which panel to focus on next.
They split on how the blood leaves your body, and on how much of the year they plan for you.
What does Empirical Health include?
The $190 panel covers 100+ biomarkers drawn in one lab visit, risk scores in the app, and Empirical Pro for tracking history.
The company's homepage walks through three steps:
- Measure — Visit a testing site and track 100+ biomarkers, including ApoB and Lp(a).
- Predict — Project how your lifetime heart risk shifts with lifestyle choices.
- Prevent — Follow a custom nutrition plan and exercise routine.
Most results arrive in 3-5 business days. The Advanced program costs $399 for 12 months and adds two retests, at 3 and 9 months, plus a doctor video visit.
What does SiPhox Health include?
SiPhox's membership includes a rotating choice of panels, a health report with an action plan, an AI assistant named Sai, supplement recommendations, an in-app body composition scan, and unlimited third-party test uploads. You pay per kit, on the cadence you pick.
SiPhox's how-it-works page lays out four steps:
- Join SiPhox Health — Pick a cadence of monthly, quarterly, or every 6 months.
- Select your health focus — Choose longevity essentials, or a targeted hormone, thyroid, or heart and metabolic panel.
- Test at home, painlessly — Use the EasyDraw kit to collect a small sample from your upper arm, with live support.
- Get insights and optimize — Results arrive in 7-10 days, with analysis and an action plan.
A partner lab holds CLIA certification and CAP accreditation, and SiPhox reports a 95%-99% correlation coefficient against standard venous draws.
What biomarkers do Empirical Health and SiPhox Health measure in 2026?
Empirical's single draw measures more biomarkers than any SiPhox panel, and SiPhox lets you change which panel you run. Empirical's count includes 26 urine items, and no SiPhox panel carries urinalysis.
| Empirical Health | SiPhox Health | |
|---|---|---|
| Initial draw | 85 lab biomarkers (72 distinct and 13 calculated) | 31 biomarkers (19 distinct and 12 calculated), or 62 (42 distinct and 20 calculated) on Ultimate 360 |
| Follow-up draw | Repeat testing at 3 and 9 months, Advanced program only | A new kit on your chosen cadence, with panel swaps |
| Headline count | 100+ biomarkers on one draw | 31 to 62 biomarkers per test |
The other three included panels are smaller still, per SiPhox's panel comparison: Hormone Focus carries 14 biomarkers, Thyroid Focus 21, and Heart & Metabolic 28.
Options beyond the base panels:
- Empirical Health — The Advanced program, with repeat testing and the doctor visit.
- SiPhox Health — Optional add-ons of CBC (+$45) and IGF-1 (+$70), and a shop with gut, allergy, cortisol, and Prenuvo MRI products.
What are the official 2026 membership prices for Empirical Health and SiPhox Health?
Empirical Health costs $190 once. SiPhox Health charges $99 for the first kit, which is an introductory price, then $124 plus $25 shipping for each renewal.
Your cadence sets the annual total. SiPhox kits renew monthly, quarterly, or every 6 months, so a year is 12, 4, or 2 kits. Ultimate 360 is a $125 upgrade.
New York and New Jersey residents pay Empirical an extra $99 lab fee, bringing the panel to $289.
Both are HSA/FSA eligible, and testing is paid out of pocket at each.
Collection: a lab draw or a kit at home
Empirical Health uses a lab draw, walk-in or booked, at a national lab network, with another partner in New York and New Jersey.
SiPhox collects at home with EasyDraw, an upper-arm device. SiPhox says the process uses no needles or finger pricks, and a prepaid FedEx label sends the sample overnight to the lab.
If lab appointments are the obstacle to testing, SiPhox removes them. If you want a lab-collected sample, Empirical keeps it.
Panel focus: one heart panel or a rotating choice
Empirical Health sets the panel and aims its depth at the heart. SiPhox lets you switch among its four included panels at no extra cost, so a thyroid focus this quarter can become heart and metabolic the next.
A SiPhox member can also upload tests from other labs, and Sai answers questions from the data, including wearable data from over 300 devices.
Prescriptions and clinician access
Empirical Health ties prescriptions to its $399 program, where the video visit covers results, a care plan, and referrals. Members can also message doctors in the app.
SiPhox does not provide clinical services itself. Medication management for Heart and Metabolic Program members comes through an independent provider group, and everyone else receives expert-overseen results and recommendations.
Coaching is a separate purchase, at $50 for one credit, in a 30-minute call or a written action plan.
Get 100+ biomarkers tested, in-lab or at home
One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.
Get 100+ biomarkers tested, in-lab or at home
One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.
Where are Empirical Health and SiPhox Health tests available?
SiPhox serves the United States and Canada except Hawaii and New York. Empirical Health lists 2,200+ testing sites, with medical services in over 30 states.
Who is Empirical Health best for, and who is SiPhox Health best for?
Empirical Health is best for:
- People whose priority is cardiovascular markers, ApoB and Lp(a) included.
- People who want a physician-read report, with a doctor visit as an option.
- People who prefer a lab-collected sample.
SiPhox Health is best for:
- People who avoid lab visits and prefer collecting at home.
- People who want to choose their own cadence and switch panels.
- People who want a biological age score and an AI assistant, plus wearable syncing.
The bottom line
Empirical Health is a heart panel with a doctor available. SiPhox Health is a flexible at-home kit with a rotating focus and room to choose how often you test.
Both stop at a report and a set of recommendations. Empirical's $190 covers one draw, with prescriptions reserved for its $399 program, while SiPhox's kits are sold one at a time and its medication management runs through an outside group.
Superpower brings those steps into a single $199 membership in most states, while Empirical's panel costs $190 once and SiPhox sells each kit at $124 plus $25 shipping after a $99 first kit. SiPhox kits renew on a cadence you pick, so its year can hold more draws than Superpower's one. Your results, synced wearables, and uploaded records go into a single Superpower AI. It drafts your Superpower Protocol and keeps coaching you as fresh data arrives. Supplements sit in the marketplace at up to 20% off beside add-on tests and scans, and prescriptions are available there when clinically appropriate, priced separately. Superpower says 93% of members found their action plan more useful, even life-changing, than a yearly checkup.
Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.
Frequently asked questions
References
- Empirical Health. (2026). Home. Empirical Health.
- Empirical Health. (2026). Advanced Heart Health program. Empirical Health.
- Empirical Health. (2026). Testing locations. Empirical Health.
- SiPhox Health. (2026). Home. SiPhox Health.
- SiPhox Health. (2026). How it works. SiPhox Health.
- SiPhox Health. (2026). Frequently asked questions. SiPhox Health.
- SiPhox Health. (2026). Panel comparison. SiPhox Health.
- SiPhox Health. (2026). Terms of service. SiPhox Health.
- SiPhox Health. (2026). State coverage. SiPhox Health.
Heart & Vascular Health
Metabolic Health
Energy
Liver Health
Kidney
Sex Hormones
Thyroid Health
Nutrients
Immune System
Inflammation