Everlywell vs OneTwenty

What is Everlywell, and what is OneTwenty?

Everlywell sells a catalog of single tests, plus Everlywell 360 for a full year of testing. Its pitch is simplicity, summed up in the line "Lab testing, simplified."

OneTwenty sells a membership it calls a physical that never ends, with quarterly bloodwork and a daily device feed. It prices at a founding-member rate until public launch.

The two differ most on how far past the first test the product reaches. Everlywell stops at one draw unless you buy more, and OneTwenty is built around four.

What does Everlywell include?

Everlywell 360 runs $399 a year and bundles one 83-biomarker test, a Care Plan reviewed by clinicians, and the WellScore. The sample is taken at a partner lab location, and the fee for it is inside the price.

Everlywell calls the experience a three-step path:

1. Schedule lab tests — Choose a lab appointment close to home and show up fasted.
2. Review your results — Clinicians go through the numbers, and you see them laid out in a dashboard.
3. Take action — Your Care Plan names the next moves, and a clinician consult is available as an add-on.

A separate product, Everlywell+, charges $39 a month for credits toward at-home kits or virtual visits. It is a different purchase from 360.

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What does OneTwenty include?

OneTwenty's membership comes to $499 a year at the founding price. That covers four lab panels, a dedicated health coach, an AI health assistant, device syncing, and unlimited uploads of old lab results.

OneTwenty describes its approach in five steps:

1. Sign up — Start one annual membership at the founding rate.
2. Schedule labs — Walk in at no added cost, or have a phlebotomist come to you for $99.
3. Connect devices and past labs — Link wearables, a scale, a blood pressure monitor, and earlier results.
4. Results plus action plan — Read each marker in plain terms, then receive a protocol from your combined data.
5. Retest quarterly — Come back every 90 days for panels on the markers worth watching.

An independent licensed provider orders each panel, and OneTwenty says it is a membership, not a medical practice.

What biomarkers do Everlywell and OneTwenty measure in 2026?

Everlywell reports 83 biomarkers once a year. OneTwenty counts 161 to 221 lab results a year, from a 101-marker baseline plus three targeted panels of 20 to 40 markers.

Neither company marks its calculated values, so the table counts both lists by one rule, with urinalysis included. Everlywell lists each white blood cell type once, which is why its own total is lower than the counted one.

OneTwenty's quarterly panels are targeted retests, so they do not repeat the baseline. Which markers return depends on what your first draw showed.

Beyond the core test, Everlywell's product range covers:

• Cancer screening — The Galleri multi-cancer test, a colon test, and a breast cancer risk assessment.
• Hormones and daily health — Thyroid, testosterone, cortisol, and vitamin D tests.
• Gut and food — A microbiome test and two food sensitivity panels.

OneTwenty's add-ons center on supplements and medications rather than extra tests:

• Custom Packs — A daily supplement pack from $67 a month.
• Medications — Medications and hormone therapy from $49 a month.
• Devices — Discounted member pricing on extra monitors and scales.

What are the official 2026 membership prices for Everlywell and OneTwenty?

Everlywell 360 is $399 a year. OneTwenty is $499 a year. That is a founding-member rate, and the site says it ends once the company launches publicly.

Everlywell is the lower annual price of the two. OneTwenty's figure buys four draws, and Everlywell's buys one.

OneTwenty bills renewals at the then-current rate. In New York and New Jersey the founding price is $749, with the same four panels, and at-home draws are required there. Everlywell 360 is not sold in either state.

Both brands' memberships can be paid with HSA/FSA funds. Everlywell calls its test eligible, and OneTwenty labels its membership reimbursement eligible, with the final call left to your plan.

How often does each one draw blood?

Everlywell takes blood once a year, and OneTwenty takes it four times.

Everlywell's annual test is complete on its own. Anything beyond it, such as a repeat marker or a second look in six months, is another purchase.

OneTwenty schedules a retest every 90 days, with focused panels on markers that need watching. That cadence suits readers who want to see a plan move numbers inside a quarter.

How do supplements and prescriptions work at each?

Both companies sell supplements and offer a prescription route, and both bill them outside the base price.

Everlywell makes its own supplements too, like a $20 Vitamin D3 bottle. Prescribing happens in a clinician consultation, only when medically appropriate, and prescriptions sit outside the membership price.

OneTwenty builds a Custom Pack from your latest panel at $67 a month and reformulates it quarterly. Medications and hormone therapy start at $49 a month through independent providers, who decide whether to prescribe. OneTwenty says lifestyle and supplements come first, "and only then medication if your data and a provider support it." There is no catalog of extra tests, so the only markers added to a member's quarterly panel are the ones a prescriber monitors during a medication.

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Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

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Who guides you after the results?

Everlywell gives you a written Care Plan and an optional consult, while OneTwenty pairs you with a coach and an AI assistant.

Everlywell's Care Plan is ready within 24 hours of your results. Choosing the 360 + Consult tier brings a live one-to-one visit with a licensed provider.

OneTwenty pairs each member with a dedicated health coach, and an AI assistant monitors incoming data as it arrives, pointing out anything worth a second look.

Where are Everlywell and OneTwenty tests available?

Everlywell 360 is not offered in Arizona, Alaska, Hawaii, New Jersey, New York, or Rhode Island, per its knowledge base.

OneTwenty serves 49 states, everywhere except Rhode Island. New York and New Jersey members pay more because state collection rules rule out its usual lab network.

Who is Everlywell best for, and who is OneTwenty best for?

Everlywell is best for:

• People who want one test and a price that never moves during the year.
• People who want a clinician-reviewed Care Plan and own-brand supplements.
• People who want a wide shelf of single-purpose kits next to the annual test.

OneTwenty is best for:

• People who want blood drawn every quarter, with a coach alongside.
• People who want wearables, a scale, and a blood pressure monitor feeding one dashboard.
• People who want custom supplement packs and medications handled in the same account.

The bottom line

Everlywell gives you one annual test with a clinician-reviewed Care Plan, at the lower of the two prices. OneTwenty gives you quarterly draws, a coach, and daily device data, at a founding rate of $499 that ends at public launch.

Each model stops at its own edge. Everlywell's prescriptions come through a paid consult, and OneTwenty sells no add-on tests or scans, with supplements and medications billed from $67 and $49 a month on top of the membership.

Superpower costs $199 a year, against $399 for Everlywell 360 and OneTwenty's $499 founding rate, the lowest of the three. That buys one draw of 100+ biomarkers and a Superpower Protocol, which Superpower AI writes from your lab results, wearable data, and medical records. Supplements at up to 20% off, plus add-on tests and scans, sit in the marketplace for when you want more, and prescriptions are available there when clinically appropriate, priced separately. Superpower reports that 93% of members found their action plan more useful, even life-changing, than a yearly checkup.

Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.