Method: Shotgun metagenomic sequencing (CLIA 21D2062464); not cleared or approved by the FDA. Results reflect relative microbial abundance for wellness education purposes. Not intended to diagnose or treat disease and not a substitute for clinical consultation. Microbial associations are based on emerging scientific research and may change over time. Derived from laboratory results. This score or index is not an FDA-cleared test. It aids clinician-directed assessment and is not a stand-alone diagnosis.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Proteobacteria/Actinobacteriota ratio testing
- Gut dysbiosis sentinel ratio tracking
- gram-negative opportunistic vs gram-positive beneficial phylum balance
What is Proteobacteria/Actinobacteriota ratio?
The Proteobacteria/Actinobacteriota ratio compares the relative abundance of Proteobacteria (a gram-negative, often opportunistic phylum) against Actinobacteriota (a phylum containing beneficial Bifidobacterium). An elevated ratio may indicate a shift toward dysbiosis.
Why is Proteobacteria/Actinobacteriota ratio important?
Elevated Proteobacteria alongside depleted Actinobacteriota is a recognized pattern associated with gut dysbiosis, antibiotic disruption, and inflammatory states. This ratio may provide a simple early signal of microbiome imbalance before specific pathogen levels reach clinically significant thresholds.
What insights will I get?
Your Proteobacteria/Actinobacteriota ratio may indicate the balance between gram-negative opportunistic bacteria and beneficial Bifidobacterium-containing taxa in your gut. An elevated ratio may prompt investigation of antibiotic history, diet, and targeted microbiome interventions.
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