Method: Shotgun metagenomic sequencing (CLIA 21D2062464); not cleared or approved by the FDA. Results reflect relative microbial abundance for wellness education purposes. Not intended to diagnose or treat disease and not a substitute for clinical consultation. Microbial associations are based on emerging scientific research and may change over time. Derived from laboratory results. This score or index is not an FDA-cleared test. It aids clinician-directed assessment and is not a stand-alone diagnosis.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Histamine-producing species testing
- Gut microbial histamine production capacity tracking
- potential histamine intolerance and immune modulation assessment
What is Histamine-producing species?
This metric estimates the aggregate abundance of gut bacteria known to produce histamine through histidine decarboxylase activity. Derived from metagenomic detection of histidine decarboxylase (hdc) gene-containing species.
Why is Histamine-producing species important?
Gut-produced histamine may contribute to circulating histamine levels and has been explored in the context of histamine intolerance, food sensitivities, and mast cell activation. Members experiencing unexplained food sensitivities, skin reactions, or allergy-like symptoms may find this metric relevant for tracking.
What insights will I get?
Your histamine-producing species score may indicate the degree to which your gut microbiome contributes to histamine production. Discuss elevated scores alongside histamine intolerance symptoms with your care team to explore dietary and microbiome-focused interventions.
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