Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of 2-3-4 Methylhippuric Acid (2,-3-,4-MHA) testing
- Xylene solvent exposure tracking
- indoor air quality assessment
- paint and adhesive chemical monitoring
What is 2-3-4 Methylhippuric Acid (2,-3-,4-MHA)?
Methylhippuric acid (MHA) isomers are urinary metabolites of xylene, a common industrial solvent found in paints, varnishes, adhesives, and cleaning products. Measured via LC-MS/MS in urine.
Why is 2-3-4 Methylhippuric Acid (2,-3-,4-MHA) important?
Xylene is a prevalent volatile organic compound (VOC) in indoor environments - fresh paint, cleaning agents, and printing products are common sources. Urinary MHA reflects recent inhalation or dermal xylene exposure and may reveal indoor air quality concerns.
What insights will I get?
Your MHA level may indicate recent xylene exposure from fresh paint, cleaning solvents, adhesives, or occupational contact. Elevated levels without obvious exposure may suggest unrecognized environmental sources in your home or workplace worth investigating.





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