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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Phenylglyoxylic acid (PGO) is a urinary metabolite of styrene and ethylbenzene, volatile organic compounds found in plastics, resins, insulation materials, and tobacco smoke.
Key benefits of Phenylglyoxylic Acid (PGO) testing
- Styrene and ethylbenzene exposure tracking
- plastics and indoor air chemical assessment
- inhalation exposure monitoring
What is Phenylglyoxylic Acid (PGO)?
PGO is a urinary metabolite of both styrene and ethylbenzene - volatile organic compounds present in polystyrene plastics, cigarette smoke, gasoline, and some building materials. Measured via LC-MS/MS with creatinine correction.
Why is Phenylglyoxylic Acid (PGO) important?
Styrene and ethylbenzene are classified as possible carcinogens at high exposures (IARC Group 2B). Urinary PGO reflects personal biological exposure - not an estimated air-level - making it a more individual measure of your styrene and ethylbenzene burden.
What insights will I get?
Your PGO level may reflect exposure to polystyrene food containers, cigarette smoke, indoor air, or fuel-related environments. Reducing use of polystyrene food packaging and avoiding tobacco smoke environments may be reflected in follow-up results.
