Key takeaway:
What is Superpower, and what is OneTwenty?
Superpower and OneTwenty are both biomarker testing companies. A biomarker testing company offers blood-based testing on a membership basis, measuring your biomarkers at set intervals. Biomarkers are measurable signals in your blood: things like cholesterol, blood sugar, and hormones.
Some platforms stop at data and a report. Others turn those numbers into a plan you can follow. Two questions separate them: how much do they measure, and what do they help you do next?
Superpower and OneTwenty answer both differently. One ships a full ecosystem today; the other tracks trends continuously, in beta.
What does Superpower include?
Superpower includes a $349/year membership covering 150+ health metrics, a personalized action plan, a built-in follow-up draw, and on-demand care-team messaging. Superpower keeps it simple:
- Join for $349 a year.
- Give your initial blood draw, at a lab or at home for an added fee.
- Get ~90 health metrics in your dashboard.
- Receive a personalized action plan.
- Give a built-in follow-up draw later, retesting ~60 biomarkers.
- Message your care team on demand.
Both draws happen at any of 2,000+ partner locations across 40+ states, or at home for an added fee. Results land in your dashboard 5 to 10 business days after each one.
Among those results is a biological-age score, included in every membership. It's a single number for your whole body, so an optional OrganAge add-on breaks it into nine organ-level scores, across systems like metabolism, inflammation, liver, and kidney health, showing you which ones are pulling the total up or down.
Acting on any of it happens in the same place. A supplement marketplace carries member-exclusive pricing, and prescriptions run through that same marketplace when clinically appropriate, priced separately. Gut microbiome testing is available as an add-on for members who want to look past blood.
What does OneTwenty include?
You give quarterly blood draws, four a year, drawn at home or at a nearby lab, and sync daily data from wearables like Oura and Apple Health, plus your continuous glucose monitor. OneTwenty runs on continuous tracking.
OneTwenty pairs your labs with an AI that reads every signal, reviewing your protocol each quarter. Licensed clinicians step in when labs indicate clinical need, and prescriptions (TRT, GLP-1, HRT) are titrated to your data when appropriate.
It sells personalized supplement packs, 50+ options, and the product is still in its founding-member beta, open by application at a $499 founder rate. Its real edge is catching trends between annual snapshots.
What biomarkers do the Superpower and OneTwenty memberships measure in 2026?
Superpower's initial draw measures ~90 biomarkers, and its headline 150+ counts the tests across both draws once a built-in follow-up retests ~60 of those same markers later in the year. OneTwenty publishes a 95+ lab biomarker baseline each year, with a custom 20+ marker panel retested every quarter on top of it. Each company states its own basis, so line the two baselines up and the panels are close in size. What separates them is cadence, and what the membership lets you do with the result.
| Superpower | OneTwenty | |
|---|---|---|
| Baseline draw | ~90 biomarkers | 95+ lab biomarkers annually |
| Retests | Built-in follow-up draw retesting ~60 markers already on the initial panel | Custom 20+ marker panel retested every quarter |
| Headline count | "150+ biomarkers" across both draws | "95+ biomarkers annually, plus a custom 20+ marker panel retested quarterly" |
Superpower's ~90 initial-draw metrics combine direct lab measurements with calculated ratios like LMR, MLR, and Ferritin:Albumin.
What support and next steps do Superpower and OneTwenty offer?
Both services act on results, but the loops differ. Superpower includes on-demand access to a care team you can message about your results, prescriptions through the marketplace when clinically appropriate and priced separately, and a curated supplement marketplace with member-exclusive pricing.
OneTwenty also offers prescriptions - TRT, GLP-1, and HRT - when clinically indicated, paired with its AI insights and quarterly clinician review.
Where they split: OneTwenty doesn't offer gut microbiome testing. Superpower keeps testing, supplements, Rx, gut testing, and care under one membership, available today.
What are the official 2026 membership prices for Superpower and OneTwenty?
Superpower costs $349 a year.
- Superpower: HSA/FSA eligible, with 20+ add-on panels available beyond the core membership.
- OneTwenty: $499/year at its founding rate, or $749/year in New York and New Jersey.
Test 150+ biomarkers
One membership, two built-in draws. Get a full picture of your health and the action plan you need to improve it.
Test 150+ biomarkers
One membership, two built-in draws. Get a full picture of your health and the action plan you need to improve it.
Who is Superpower best for, and who is OneTwenty best for?
Superpower is best for:
- People who want to spend less.
- People who want a protocol and care, not just data.
- People who want a deep baseline without a quarterly draw schedule.
- People who want supplement, gut, and prescription access in one place.
- People who want to start today.
OneTwenty is best for:
- Data-driven optimizers who want quarterly trend tracking.
- People who want tight wearable integration.
- People comfortable with beta access while it scales.
The final word: does Superpower or OneTwenty fit you?
OneTwenty's continuous quarterly-plus-wearable tracking is a genuine draw for trend-watchers, and it offers prescriptions too, at $499 a year for a model still gated behind founding-member beta applications. OneTwenty bets on frequency: four draws a year, daily wearable sync, and a protocol an AI revises every quarter as new data lands.
The tradeoff is timing. A trend line only means something once there's a baseline to measure it against, and that baseline doesn't arrive until OneTwenty's beta opens to you and its first quarterly cycle completes. Whether that wait is worth it depends on whether you're solving for continuous monitoring or for a complete picture you can act on right away.
Superpower: a complete baseline available today, at a lower price
Where OneTwenty's beta leaves you waiting for quarterly draws to add up into a wearable-fed trend line, Superpower gives you a complete baseline from a single initial draw. It comes with a personalized action plan and on-demand care-team messaging between tests, at $349 a year against OneTwenty's $499, and it's live today rather than application-gated. And a first complete picture often turns up something routine care missed: 60% of members said Superpower identified something previously missed or overlooked by a doctor.
Starting your own health picture doesn't have to wait for a beta invite to open up. Start a Superpower membership and get your first baseline draw scheduled today.
Heart & Vascular Health
Metabolic Health
Energy
Liver Health
Kidney
Sex Hormones
Thyroid Health
Nutrients
Immune System
Inflammation