Key takeaway:
What is Superpower, and what is OneTwenty?
Superpower is a home for health, an all-in-one platform that gathers your testing and guidance in one place. One yearly membership folds in AI health coaching and wearable data tracking alongside biomarker testing and a personalized action plan. Members also get their own marketplace for supplements and add-on tests, with prescriptions available when clinically appropriate, priced separately.
OneTwenty is a health optimization membership, in its own words "not a medical practice." It describes the membership as quarterly bloodwork, daily data from your devices, and a protocol that updates as both arrive. It is accepting founding members at founding-member pricing ahead of its public launch.
Both bring lab results, wearable data, and AI into one membership. Testing frequency, add-ons beyond blood, and the source of supplements and prescriptions are where the two part ways.
What does Superpower include?
A Superpower membership costs $199 a year. That gets you a personalized action plan plus 100+ biomarkers in a single draw, backed by AI and care team support. Wearable and medical record integration is included, and a members-only marketplace sells add-on tests and supplements.
New members follow a simple path:
- Join for $199 a year.
- Add your wearables, plus any medical records, past lab results, and AI chats you already have.
- Choose a partner lab for your draw, or have it done at home for $119 more.
- Your health metrics appear in the dashboard within 10 days.
- Your first Superpower Protocol follows, an action plan covering lifestyle changes, supplements, and more.
- Bring questions about your results to AI and care team support.
Your dashboard renders that data as a digital twin, a 3D model made from your metrics. Uploaded medical records, wearable data, and earlier lab results start producing insights before your draw is processed.
Every member sees two scores. Your Superpower Score shows how near you are to optimal levels across every biomarker, and your biological age is a single number for your whole body. Fresh lab results shift both, so you can see what is changing.
You never have to leave the platform to act on your results. Add-on panels and scans sit in the member marketplace beside supplements discounted up to 20%, while prescriptions are available when clinically appropriate, priced separately.
What does OneTwenty include?
A OneTwenty membership costs $499 a year at founding-member pricing and includes four lab panels, daily device syncing, an AI health assistant, a dedicated health coach, and unlimited uploads of past lab results. Custom supplement packs and medications are add-ons billed on top.
OneTwenty publishes a five-step process:
- Sign up — One membership, $499 a year.
- Schedule labs — A walk-in draw near you at no extra cost, or a phlebotomist at your door for $99, with the panel ordered by an independent licensed provider.
- Connect devices and past labs — Ring, watch, scale, blood pressure cuff, glucose monitor, and every lab result you already have.
- Results plus action plan — Every marker explained, then a protocol built from your labs, wearable data, and body data.
- Retest quarterly — Focused panels every 90 days on the markers that need watching.
The protocol runs in three tiers: lifestyle coaching first, then custom supplement packs, then prescriptions through independent licensed providers where they help. Every member also gets One Health Score, a 0 to 100 score that OneTwenty builds on the American Heart Association's Life's Essential 8.
What biomarkers do Superpower and OneTwenty measure in 2026?
Superpower measures 100+ biomarkers in one draw a year. OneTwenty publishes a 101-marker baseline, then a custom 20 to 40 marker panel each quarter, for 161 to 221 lab results a year.
OneTwenty does not label its calculated markers, so we counted them. Its list of 101 includes seven sex-specific markers and two panel names, CBC and urinalysis, whose results are listed one by one. Each member's baseline carries 94 or 97 biomarkers, eight of them calculated.
| Superpower | OneTwenty | |
|---|---|---|
| Baseline draw | 103 biomarkers (57 distinct and 46 calculated) | 94-97 biomarkers (86-89 distinct and 8 calculated) |
| Headline count | 100+ biomarkers in one draw | 161 to 221 lab results a year |
Superpower's draw lists more biomarkers than OneTwenty's baseline, 103 to 94-97, but OneTwenty measures more of its own directly, 86-89 to 57, and pulls further ahead across the year with its quarterly panels. Both baselines cover heart, metabolic, hormone, thyroid, kidney, liver, and blood-count markers, and OneTwenty's also includes urinalysis. OneTwenty's carries several that Superpower's draw does not, such as Lp(a), homocysteine, vitamin B12, and PSA. Superpower sells Lp(a) separately as the Lipoprotein (a) Add-on. Superpower's draw includes cortisol, GGT, and uric acid, which OneTwenty's list does not.
Superpower's marketplace also sells add-ons:
- Advanced scans — DEXA bone density, a whole-body MRI provided by Prenuvo, heart calcium, DEXA body composition, and VO2 max.
- Brain and cognitive health — ApoE genetic risk, plus amyloid plaque and tau protein screening.
- Specialty screening — Whole genome sequencing, an organ age panel, and gut microbiome analysis.
- Hormone and reproductive health — Active testosterone, egg reserve, sperm analysis, and prostate screening.
- Toxins and nutrition — Vitamin, mineral, and organic acids panels, plus environmental toxins, heavy metals, mycotoxins, and methylation.
OneTwenty does not sell scans or specialty tests. Its add-on biomarkers are the markers a prescribed medication adds to your quarterly panel.
What are the official 2026 membership prices for Superpower and OneTwenty?
Superpower costs $199 a year. OneTwenty costs $499 a year at founding-member pricing, which it says ends at public launch.
Neither price is completely flat. An at-home draw adds $119 to Superpower. State fees in New York and New Jersey raise membership there to $399 a year. OneTwenty includes walk-in draws and charges $99 for an at-home draw. In New York and New Jersey, its membership costs $749 a year, with the same four panels, and at-home draws are required there.
OneTwenty bills Custom Packs from $67 a month and medications from $49 a month on top of the membership. On Superpower, add-on panels, tests, and scans cost extra, and prescriptions are priced separately. Both memberships are HSA/FSA eligible, OneTwenty's depending on your plan, so pre-tax dollars can cover either one.
How often do Superpower and OneTwenty test?
OneTwenty tests more often: four draws a year to Superpower's one, each inside its membership price. Frequency is the center of OneTwenty's model, and it is a real strength.
OneTwenty's year runs a full baseline, then a targeted panel of 20 to 40 markers every 90 days, chosen from what the baseline found. In its words, each retest "re-measures that same set so you can see a real trend, not a single reading that happened to swing."
Superpower measures once a year, 100+ biomarkers in a single draw, with no retest inside the membership. In place of frequency it puts weight on what follows the draw: a $199 membership that writes and revises your protocol, keeps AI and care team support on call, and sells add-on panels and scans through the marketplace when a question gets more specific.
How do Superpower and OneTwenty support you after results?
Both pair AI with people: OneTwenty with a dedicated health coach and independent licensed providers, Superpower with AI and care team support.
OneTwenty's AI health assistant monitors incoming data, answers questions from your own results, and flags anything worth a closer look, with monthly AI-generated health reviews. Your coach walks you through each panel, and independent licensed providers handle anything clinical. That coach is a real difference for anyone who wants a person guiding them through every result.
Your protocol on Superpower is written and revised by Superpower AI, which draws on lab results, wearable data, medications, medical history, and any context you share. Health coaching runs all year, and AI and care team support answers questions whenever they come up.
Both read devices and import past lab results. OneTwenty connects Oura and Withings directly, including a smart scale and blood pressure monitor, and Superpower integrates directly with Apple Health, Whoop, Oura, and more.
Where are Superpower and OneTwenty available?
2,000+ partner lab locations serve Superpower members in 41 states and Washington, D.C., and at-home draws reach most regions. Superpower has not launched yet in Alaska, Arkansas, Hawaii, Louisiana, Mississippi, North Dakota, Rhode Island, South Dakota, or Wyoming.
OneTwenty is available in 49 states, all but Rhode Island, and draws through a national lab network. New York and New Jersey collection laws rule out that network, which is why members there pay more and are drawn at home.
Get 100+ biomarkers tested, in-lab or at home
One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.
Get 100+ biomarkers tested, in-lab or at home
One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.
Comparing member marketplaces
Superpower members get their own marketplace, where add-on tests are sold alongside supplements marked down by up to 20%. Prescription medications compounded in the USA (like peptides) are also available when clinically appropriate, priced separately.
OneTwenty sells one supplement product: Custom Packs, a daily pack cut from your latest panel and re-formulated every quarter, from $67 a month. Medications and hormone therapy come through independent licensed providers, from $49 a month, and only after lifestyle changes and supplements, "if your data and a provider support it." There is no storefront for other brands' supplements, and no add-on tests.
Who is Superpower best for, and who is OneTwenty best for?
Superpower is best for:
- People who want scans and brain, genome, and gut tests available in the same membership as their blood work.
- People who want to choose supplements from a member-priced storefront rather than take one custom pack.
- People who want AI to turn every metric they track into personalized insights and coaching.
- People who want one broad draw a year instead of a quarterly draw schedule.
OneTwenty is best for:
- People who want bloodwork every quarter, with retests aimed at the markers that need watching.
- People who want a dedicated health coach.
- People who want smart scale and blood pressure readings feeding the same protocol as their labs.
- People who want their full lab history on the same graphs, with unlimited uploads.
- People in states Superpower has not reached yet, since OneTwenty covers 49.
OneTwenty vs Superpower: the bottom line
With either company, you get real data and a protocol built from it. OneTwenty's quarterly panels, daily device sync, and dedicated health coach make it one of the closest models to Superpower's, and it retests more often. But it sells no scans or specialty tests, and its supplements and medications are monthly add-ons on top of the membership. On price, OneTwenty's founding-member $499 a year sits above Superpower's $199, which makes it the more expensive of the two.
Superpower keeps the rest in one place. Your 100+ biomarkers from one annual draw sit next to scans and brain, genome, and gut tests you can add when a question gets specific. Supplements your protocol recommends carry member pricing in the marketplace, and prescriptions are available when clinically appropriate, priced separately. Superpower says 93% of members found their action plan more useful, even life-changing, than a yearly checkup.
Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.
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